Knowledge Base

TSKgel UP-SW3000, 2 um SEC columns

Column-to-column reproducibility

Lot-to-lot reproducibility

mAb analysis using TSKgel UP-SW3000 column

TSKgel UP-SW3000 columns are designed for the analysis of monoclonal antibodies and other biopharma products and can be used on both HPLC and UHPLC systems. The columns are packed with 2 μm silica-based beads shielded with a hydrophilic diol-type bonded phase that prevents the silica surface from interacting with protein samples.

TSKgel UP-SW3000 columns feature the same pore size as the well-established TSKgel G3000SWxl columns. Hence methods developed using TSKgel G3000SWxl columns can easily be transferred to TSKgel UP-SW3000 columns on conventional HPLC systems as well as on UHPLC systems.

TSKgel UP-SW3000 columns offer higher resolution, improved peak shape and increased efficiency yielding methods that are robust, reproducible and easily transferrable between UHPLC and HPLC systems.

TSKgel UP-SW3000 columns offer superior reproducibility injection-to-injection, from column-to-column within the same lot and from lot-to-lot. %RSD values for peak parameters including retention times, area peak height, peak asymmetry, and theoretical plate count demonstrate the exceptional reproducibility of these columns.

Increased resolution
- Up to 35% increased resolution versus conventional SEC HPLC columns
Time and solvent savings
- 50% reduction in run time compared with use of conventional HPLC system
Robust and highly reproducible
- Superior injection-to-injection, column-to-column and lot-to-lot reproducibility
Easy and cost effective method transfer
- Minimal method development required
Brand name reputation

TSKgel is the industry standard for mAb analysis

Product Attributes:

Base material: Silica

Particle size (mean): 2 μm

Pore size (mean): 25 nm

Functional group: Diol

pH stability: 2.5-7.5

Calibration range: 10-500 kDa (proteins)

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